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Rilapladib
CAS No. 412950-08-4
Rilapladib( SB-659032 | SB 659032 )
Catalog No. M14414 CAS No. 412950-08-4
A potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 368 | In Stock |
|
| 5MG | 227 | In Stock |
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| 10MG | 369 | In Stock |
|
| 25MG | 566 | In Stock |
|
| 50MG | 770 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | 1553 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRilapladib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM.
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DescriptionA potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM, for the treatment of Alzheimer's disease and atherosclerosis.Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsSB-659032 | SB 659032
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number412950-08-4
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Formula Weight735.814
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Molecular FormulaC40H38F5N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 86.67 mg/mL 117.79 mM; H2O : < 0.1 mg/mL
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SMILESO=C(N(C1CCN(CCOC)CC1)CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)CN4C(SCC5=CC=CC(F)=C5F)=CC(C6=C4C=CC=C6)=O
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Chemical Name2-(2-((2,3-difluorobenzyl)thio)-4-oxoquinolin-1(4H)-yl)-N-(1-(2-methoxyethyl)piperidin-4-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tawakol A, et al. J Am Coll Cardiol. 2014 Jan 7-14;63(1):86-8.
2. Shaddinger BC, et al. PLoS One. 2014 Jan 27;9(1):e83094.
3. Wilensky RL, et al. Curr Opin Lipidol. 2009 Oct;20(5):415-20.
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