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Rilapladib

CAS No. 412950-08-4

Rilapladib( SB-659032 | SB 659032 )

Catalog No. M14414 CAS No. 412950-08-4

A potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rilapladib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM.
  • Description
    A potent, selective and oral lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.23 nM, for the treatment of Alzheimer's disease and atherosclerosis.Alzheimer Disease Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB-659032 | SB 659032
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    Phospholipase
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    412950-08-4
  • Formula Weight
    735.814
  • Molecular Formula
    C40H38F5N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 86.67 mg/mL 117.79 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(N(C1CCN(CCOC)CC1)CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)CN4C(SCC5=CC=CC(F)=C5F)=CC(C6=C4C=CC=C6)=O
  • Chemical Name
    2-(2-((2,3-difluorobenzyl)thio)-4-oxoquinolin-1(4H)-yl)-N-(1-(2-methoxyethyl)piperidin-4-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tawakol A, et al. J Am Coll Cardiol. 2014 Jan 7-14;63(1):86-8. 2. Shaddinger BC, et al. PLoS One. 2014 Jan 27;9(1):e83094. 3. Wilensky RL, et al. Curr Opin Lipidol. 2009 Oct;20(5):415-20.
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