DPTIP( —— )

Catalog No. M28511 CAS No. 351353-48-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

DPTIP
Note

Research use only, not for human use.
Brief Description

DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
Description

DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.(In Vitro):DPTIP (30 μM) decreases exosome release by 50% in astrocytes. DPTIP(0.03-30 μM) dose-dependently blocks EV secretion.(In Vivo):In mice, DPTIP potently (10 mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4 h after the administration of DPTIP.
In Vitro

DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes.
In Vivo

DPTIP potently (10?mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release. Animal Model:Mice.Dosage:10?mg/kg.Administration:IP 0.5?h prior to IL-1β striatal injection.Result:Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4?h after compound administration.The number of astrocyte-derived EVs was reduced by 51?±?13% 2?h post IL-1β administration.
Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

Phospholipase
Recptor

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Research Area

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Indication

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