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(R)-Serine
CAS No. 312-84-5
(R)-Serine( —— )
Catalog No. M21605 CAS No. 312-84-5
(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | 29 | In Stock |
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Biological Information
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Product Name(R)-Serine
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NoteResearch use only, not for human use.
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Brief Description(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.
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Description(R)-Serine is an endogenous amino acidis a potent co-agonist at the NMDA glutamate receptor.(In Vitro):(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.(In Vivo):(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.
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In Vitro(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.
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In Vivo(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain. Animal Model:Four week old male C57Bl/6 miceDosage:10 g/LAdministration:Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeksResult:Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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RecptorNMDA receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number312-84-5
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Formula Weight105.09
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Molecular FormulaC3H7NO3
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Purity>98% (HPLC)
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SolubilityH2O:50 mg/mL (475.78 mM)
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SMILESN[C@H](CO)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dai X et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.
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