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Ro 8-4304 Hydrochloride
CAS No. 195988-65-9
Ro 8-4304 Hydrochloride( —— )
Catalog No. M21953 CAS No. 195988-65-9
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 272 | In Stock |
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| 10MG | 408 | In Stock |
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| 25MG | 613 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRo 8-4304 Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionRo 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.
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DescriptionRo 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil. The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively. Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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RecptorNMDA receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number195988-65-9
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Formula Weight406.9
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Molecular FormulaC21H24ClFN2O3?
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(=O)c1ccc(OCC(O)CN2CCC(=CC2)c2ccc(F)cc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kew J N C , Trube G , Kemp J A . State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist[J]. British Journal of Pharmacology, 1998, 123(3):463-472.2. Huang S , Balgi A , Pan Y , et al. Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics[J]., 2016, 009(012):1620-1633.
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