Anisodamine Hydrobromide( 6-Hydroxyhyoscyamine )

Catalog No. M21541 CAS No. 55449-49-5

Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.

Purity : >98% (HPLC)

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Biological Information

Product Name

Anisodamine Hydrobromide
Note

Research use only, not for human use.
Brief Description

Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
Description

Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
In Vitro

Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
In Vivo

Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%. Animal Model:LPS-Induced Shock Mice Dosage:50 mg/kg Administration:I.p.Result:Markedly decreased the mortality to 20%.
Synonyms

6-Hydroxyhyoscyamine
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

α1-adrenergic receptor
Research Area

Metabolic Disease
Indication

Intestinal Diseases

Chemical Information

CAS Number

55449-49-5
Formula Weight

386.28
Molecular Formula

C17H24BrNO4
Purity

>98% (HPLC)
Solubility

DMSO:77 mg/mL (199.34 mM)
SMILES

Br.[H][C@@]12C[C@H](O)[C@@]([H])(C[C@H](C1)OC(=O)[C@H](CO)C1=CC=CC=C1)N2C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang WW et al. Differential Neuropsychopharmacological Influences of Naturally Occurring Tropane Alkaloids Anisodamine Versus Scopolamine. Neurosci Lett. 2008 Oct 10;443(3):241-5.

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