Lutein

Research use only, not for human use.

Lutein has antitumour action, is potentially useful for treating macular degeneration.

Lutein is a xanthophyll found in the major light-harvesting protein complexes of plants. Dietary lutein accumulates in the macula lutea.(In Vitro):Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation.(In Vivo):Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats.Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.

Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation.

Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats.Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. Animal Model:Sprague-Dawley rats, severe traumatic brain injury (STBI) modelDosage:40, 80 and 160 mg/kg Administration:In diet for 5 weeks Result:Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.Animal Model:Male Swiss mice, chronic Corticosterone (HY-B1618) model of depressionDosage:0.1, 1 and 10 mg/kg Administration:Oral administration, once or daily for 7 and 21 days Result:Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.

Lutein | Xanthophyll

Angiogenesis

Adrenergic Receptor

Antibacterial

Cancer|Infection

——

127-40-2

568.88

C40H56O2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (87.89 mM)

CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)O)C)C)C

beta,epsilon-Carotene-3,3'-diol

(-20℃)

With Ice Pack

≥ 2 years