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Home - Products - Metabolic Enzyme/Protease - Phosphatase - Raphin1

Raphin1

CAS No. 2022961-17-5

Raphin1( —— )

Catalog No. M21085 CAS No. 2022961-17-5

Raphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Raphin1
  • Note
    Research use only, not for human use.
  • Brief Description
    Raphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
  • Description
    Raphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
  • In Vitro
    Raphin1 causes a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.
  • In Vivo
    Raphin1 improves weight of HD82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2022961-17-5
  • Formula Weight
    231.08
  • Molecular Formula
    C8H8Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(540.94 mM ;?
  • SMILES
    N=C(N)N/N=C/c1cccc(Cl)c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Krzyzosiak A Sigurdardottir A Luh Let al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23 ;174(5):1216-1228.e19.?
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