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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DS-1001b

DS-1001b

CAS No. 1898207-64-1

DS-1001b( —— )

Catalog No. M21053 CAS No. 1898207-64-1

DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
5MG 68 In Stock
10MG 116 In Stock
25MG 187 In Stock
50MG 276 In Stock
100MG 431 In Stock
200MG 621 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    DS-1001b
  • Note
    Research use only, not for human use.
  • Brief Description
    DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • Description
    DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1).
  • In Vitro
    Cell Proliferation Assay Cell Line:JJ012, L835 Concentration:0.1, 1, 10 μM Incubation Time:14 days Result:Inhibited cell proliferation in a dose-dependent manner. GI50 values for JJ012, L835 are 81 and 77 nM.RT-PCR Cell Line:L835 Concentration:10 μM Incubation Time:6 weeks Result:Upregulated the expression of SOX9, RUNX2, COL2A1, COL10A1 and ACAN.Cell Cycle Analysis Cell Line:JJ012 Concentration:1 μM Incubation Time:7 days Result:Induced G1 phase arrest. Increased the percentage of cells in the G0/G1 phase by 5.4% and decreased that of cells in the S phase by 4.4%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    IDH1
  • Research Area
    Cancer
  • Indication
    Glioma

Chemical Information

  • CAS Number
    1898207-64-1
  • Formula Weight
    608.92
  • Molecular Formula
    C29H29Cl3FN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:14 mg/mL (22.99 mM)
  • SMILES
    CC(C)(C)N.Cc1cn(C(=O)c2c(-c3c(Cl)cc(Cl)cc3Cl)noc2C(C)(C)F)c2cccc(/C=C/C(=O)O)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yoshiki A Yohei M Toshihiko W et al. ACT-14 A FIRST-IN-HUMAN STUDY OF MUTANT IDH1 INHIBITOR DS-1001B IN PATIENTS WITH RECURRENT GLIOMAS[J]. Neuro Oncology Advances(Supplement_2):Supplement_2.
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