Orotic acid

Research use only, not for human use.

Orotic acid (OA) is an intermediate in pyrimidine metabolism. Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.

Orotic acid (OA) is an intermediate in pyrimidine metabolism. Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.(In Vitro):Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.(In Vivo):Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.

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Metabolic Enzyme/Protease

Dehydrogenase

DHOase

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65-86-1

156.1

C5H4N2O4

>98% (HPLC)

DMSO: 2 mg/mL (12.81 mM)

OC(=O)C1=CC(=O)NC(=O)N1

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(-20℃)

With Ice Pack

≥ 2 years