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Qc1
CAS No. 403718-45-6
Qc1( Qc 1 )
Catalog No. M27692 CAS No. 403718-45-6
Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 93 | In Stock |
|
| 25MG | 164 | In Stock |
|
| 50MG | 242 | In Stock |
|
| 100MG | 351 | In Stock |
|
| 200MG | 498 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameQc1
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NoteResearch use only, not for human use.
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Brief DescriptionQc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.
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DescriptionQc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.(In Vitro):Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine and blocks the charging of tetrahydrofolate(THF). In ES cells, Qc1 (10 μM) increases autophagic activity.
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In VitroQc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity.. Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine.
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In Vivo——
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SynonymsQc 1
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorPAR-1|Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number403718-45-6
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Formula Weight455.45
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Molecular FormulaC23H16F3N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (137.23 mM)
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SMILESFC(F)(F)c1cccc(c1)N1C(=S)N=C2C=C(C=C[C@@H]2C1=O)C(=O)NCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Di Serio C, et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxicol. 2007 Jul;101(1):63-9.
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