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Home - Products - Metabolic Enzyme/Protease - Phosphatase - KY-226

KY-226

CAS No. 1621673-53-7

KY-226( —— )

Catalog No. M20927 CAS No. 1621673-53-7

KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 122 In Stock
5MG 116 In Stock
10MG 170 In Stock
25MG 282 In Stock
50MG 431 In Stock
100MG 690 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    KY-226
  • Note
    Research use only, not for human use.
  • Brief Description
    KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)
  • Description
    KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM).
  • In Vitro
    Western Blot Analysis Cell Line:bEnd.3 cells stimulated with LPS Concentration:1 μM Incubation Time:24 hours Result:Rescued lipopolysaccharide-induced reduction of mRNA and protein levels of ZO-1.
  • In Vivo
    Animal Model:Male db/db mice (8-11 weeks old)Dosage:10 mg/kg and 30 mg/kg Administration:Oral administration; daily; for 4 weeks Result:Significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    PTP1B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1621673-53-7
  • Formula Weight
    481.67
  • Molecular Formula
    C27H31NO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (519.03 mM)
  • SMILES
    CCCCCCS(=O)(=O)NC(=O)c1ccc(CSCc2ccc(-c3ccccc3)cc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ito Y Fukui M Kanda M et al. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice[J]. Journal of Pharmacological Sciences 2018:S1347861318300422.
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