Cart
sales@molnova.com
NSC 95397
CAS No. 93718-83-3
NSC 95397( —— )
Catalog No. M21001 CAS No. 93718-83-3
NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 187 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 524 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNSC 95397
-
NoteResearch use only, not for human use.
-
Brief DescriptionNSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
-
DescriptionNSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
-
In VitroCell Viability Assay Cell Line:Human colon cancer cell lines, SW480, SW620, and DLD-1Concentration:0, 10, and 20 μM Incubation Time:24 hours Result:The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively.Western Blot Analysis Cell Line:SW480, SW620, and DLD-1 cells Concentration:10 μM Incubation Time:24 hours Result:p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetPhosphatase
-
RecptorPhosphatase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number93718-83-3
-
Formula Weight310.39
-
Molecular FormulaC14H14O4S2
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (322.18 mM)
-
SMILESO=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21
-
Chemical Name23-Bis(2-hydroxyethylsulfanyl)naphthalene-14-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Navneet D Bou-Yue P Chien-Min L et al. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway[J]. International Journal of Molecular Sciences 2018 19(6):1625-.
molnova catalog
related products
-
Pentamidine dihydroc...
Pentamidine dihydrochloride is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii).
-
CCT007093
CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.
-
SC-43
SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.SC-43, a sorafenib derivative.
