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NSC 95397
CAS No. 93718-83-3
NSC 95397( —— )
Catalog No. M21001 CAS No. 93718-83-3
NSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 187 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 524 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC 95397
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
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DescriptionNSC 95397 is a potent inhibitor of Cdc25 dual specificity phosphatase(Ki of 32 96 and 40 nM for Cdc25A Cdc25B and Cdc25C respectively).
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In VitroCell Viability Assay Cell Line:Human colon cancer cell lines, SW480, SW620, and DLD-1Concentration:0, 10, and 20 μM Incubation Time:24 hours Result:The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively.Western Blot Analysis Cell Line:SW480, SW620, and DLD-1 cells Concentration:10 μM Incubation Time:24 hours Result:p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number93718-83-3
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Formula Weight310.39
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Molecular FormulaC14H14O4S2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (322.18 mM)
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SMILESO=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21
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Chemical Name23-Bis(2-hydroxyethylsulfanyl)naphthalene-14-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Navneet D Bou-Yue P Chien-Min L et al. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway[J]. International Journal of Molecular Sciences 2018 19(6):1625-.
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