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BCI
CAS No. 1245792-51-1
BCI( (E)-BCI )
Catalog No. M22447 CAS No. 1245792-51-1
BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
|
| 5MG | 114 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 297 | In Stock |
|
| 50MG | 439 | In Stock |
|
| 100MG | 619 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBCI
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NoteResearch use only, not for human use.
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Brief DescriptionBCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
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DescriptionBCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
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In VitroWestern Blot Analysis Cell Line:RAW264.7 macrophage cells Concentration:100 ng/mL Incubation Time:24 hours Result:Showed DUSP6 protein downregulation.RT-PCR Cell Line:RAW264.7 macrophage cells Concentration:0-1 nM Incubation Time:24 hours Result:Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.
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In Vivo——
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Synonyms(E)-BCI
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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Recptorphosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number1245792-51-1
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Formula Weight317.42
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Molecular FormulaC22H23NO
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (393.80 mM; Need ultrasonic)
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SMILESO=C1c2ccccc2C(NC2CCCCC2)\C1=C/c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
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