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Rbin-1

CAS No. 328023-11-6

Rbin-1( Ribozinoindole-1 )

Catalog No. M20815 CAS No. 328023-11-6

Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	67	In Stock
5MG	61	In Stock
10MG	92	In Stock
25MG	217	In Stock
50MG	368	In Stock
100MG	548	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Rbin-1
Note

Research use only, not for human use.
Brief Description

Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.
Description

Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.
In Vitro

Rbin-1 is a potent and reversible triazinoindole-based inhibitors of eukaryotic ribosome biogenesis. Rbin-1 inhibits recombinant full-length Mdn1’s ATPase activity. Two of the active analogs (Rbin-1 and Rbin-2) inhibit the ATPase activity by 40% at 1 uM. In particular, an analog (Rbin-2) with a bromine substituent at postion-7 is 10-fold more active than Rbin-1 (GI50=14±1 nM (Rbin-2); 136±7 nM (Rbin-1), n=4, mean±SD).
In Vivo

——
Synonyms

Ribozinoindole-1
Pathway

Endocrinology/Hormones
Target

ATPase
Recptor

ATPase
Research Area

——
Indication

——

Chemical Information

CAS Number

328023-11-6
Formula Weight

256.33
Molecular Formula

C13H12N4S
Purity

>98% (HPLC)
Solubility

DMSO:31 mg/mL (120.94 mM)
SMILES

C=C(C)CSc1nnc2c(n1)[nH]c1ccccc12
Chemical Name

3-((2-Methylallyl)thio)-5H-[124]triazino[56-b]indole

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Structural Insights into Mdn1 an Essential AAA Protein Required for Ribosome Biogenesis.

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