ω-Conotoxin GVIA( —— )

Catalog No. M30726 CAS No. 106375-28-4

COA

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Product Name

ω-Conotoxin GVIA
Note

Research use only, not for human use.
Brief Description

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
Description

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
In Vitro

ω-conotoxin GVIA (50 nM, 50 nL) inhibits the effects of urotensin II (UII).
In Vivo

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Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

——
Research Area

——
Indication

——

CAS Number

106375-28-4
Formula Weight

3037
Molecular Formula

C120H182N38O43S6
Purity

>98% (HPLC)
Solubility

water:1 mg/mL
SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O
Chemical Name

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1. Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431 PMID:

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