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Home - Products - GPCR/G Protein - Calcium Channel - Imagabalin hydrochloride

Imagabalin hydrochloride

CAS No. 610300-00-0

Imagabalin hydrochloride( PD-0332334 | PD-332334 )

Catalog No. M15290 CAS No. 610300-00-0

Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Imagabalin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2.
  • Description
    Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2; demonstrated preclinical efficacy of anxiolytic, analgesic, hypnotic, and anticonvulsant-like activity for the treatment of generalized anxiety disorder.Anxiety Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    β-Amino Acid Imagabalin Hydrochloride had been in phase III clinical trials for the treatment of generalised anxiety disorders. However, this research has been discontinued. β-Amino Acid Imagabalin Hydrochloride had been also in phase I clinical trials for the treatment of chronic kidney disease.
  • Synonyms
    PD-0332334 | PD-332334
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    610300-00-0
  • Formula Weight
    209.714
  • Molecular Formula
    C9H20ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC[C@@H](C)C[C@H](N)CC(O)=O.[H]Cl
  • Chemical Name
    (3S,5R)-3-amino-5-methyloctanoic acid hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Quintero JE, et al. Brain Res. 2011 Jul 15;1401:1-9.
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