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Home - Products - GPCR/G Protein - Histamine Receptor - JNJ-5207852

JNJ-5207852

CAS No. 398473-34-2

JNJ-5207852( —— )

Catalog No. M20744 CAS No. 398473-34-2

JNJ-5207852 is a novel non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 31 In Stock
5MG 29 In Stock
10MG 46 In Stock
25MG 95 In Stock
50MG 184 In Stock
100MG 271 In Stock
200MG 384 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-5207852
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-5207852 is a novel non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
  • Description
    JNJ-5207852 is a novel non-imidazole histamine H3 receptor antagonist with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
  • In Vitro
    ——
  • In Vivo
    JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels. Animal Model:Male, Sprague-Dawley ratsweighing 282-334 g.Dosage:3, 10, 30 mg/kg.Administration:S.C. Result:Iincreased time spent awake and decreased REM sleep and slow-wave sleep.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    H3 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    398473-34-2
  • Formula Weight
    316.48
  • Molecular Formula
    C20H32N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:77.5 mg/mL (244.88 mM)
  • SMILES
    C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Esbenshade T A Browman K E Bitner R S et al. The histamine H3 receptor: an attractive target for the treatment of cognitive disorders[J]. 2008 154(6):1166-1181.
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