Levocetirizine( Levocetirizine | Xarlin | Xusal )

Catalog No. M11207 CAS No. 130018-77-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Levocetirizine
Note

Research use only, not for human use.
Brief Description

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
Description

Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist. (In Vivo):Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats.
In Vitro

——
In Vivo

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats. Animal Model:30 male Sprague-Dawley rats (8 weeks old; 200-250 g) Dosage:0.4 mg/kg Administration:Oral administration (Pharmacokinetic Analysis)Result:The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.
Synonyms

Levocetirizine | Xarlin | Xusal
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

H1 receptor
Research Area

——
Indication

——

CAS Number

130018-77-8
Formula Weight

388.89
Molecular Formula

C21H25ClN2O3
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
Chemical Name

Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-

1.Pasquali M, et al. Clin Exp Allergy. 2006 Sep;36(9):1161-7.

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