Cart
sales@molnova.com
Home - Products - Microbiology/Virology - Antibiotic - TBAJ-587

TBAJ-587

CAS No. 2252316-16-6

TBAJ-587( —— )

Catalog No. M20563 CAS No. 2252316-16-6

TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 265 In Stock
5MG 188 In Stock
10MG 297 In Stock
25MG 566 In Stock
50MG 788 In Stock
100MG 1051 In Stock
200MG 1423 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TBAJ-587
  • Note
    Research use only, not for human use.
  • Brief Description
    TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.
  • Description
    TBAJ-587 is a potent anti-tuberculosis agent. TBAJ-587 inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay respectively. BAJ-587 has more potent activity against M. tuberculosis and better efficacy in animal models of TB.
  • In Vitro
    Bedaquiline is adrug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability due to its potent inhibition of the cardiac potassium channel protein hERG. TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade. TBAJ-587 inhibits hERG channel with an IC50 of 13 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antibiotic
  • Recptor
    tuberculosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2252316-16-6
  • Formula Weight
    614.5
  • Molecular Formula
    C30H33BrFN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 43.33 mg/mL (70.51 mM)
  • SMILES
    COc1cc(cc(OC)n1)C(O)(CCN(C)C)C(c1cccc(OC)c1F)c1cc2cc(Br)ccc2nc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sutherland H S Tong A S T Choi P J et al. 35-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel[J]. Bioorganic & Medicinal Chemistry 2019.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Penicillic acid

    Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro.?

  • Sulbactam

    Sulbactam(Betamaze) is an irreversible β-lactamase inhibitor.

  • Diethylamine NONOate...

    Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) is a nitric oxide donor with antibacterial activity, a dispersant for preformed biofilms of Pseudomonas aeruginosa and inhibits the growth of E. coli.

Sign In Join Free