nafcillin sodium( —— )

Catalog No. M15744 CAS No. 7177-50-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

nafcillin sodium
Note

Research use only, not for human use.
Brief Description

Nafcillin sodium salt monohydrate is a semi-synthetic antibiotic related to penicillin.
Description

Nafcillin sodium salt monohydrate is a semi-synthetic antibiotic related to penicillin.(In Vivo):Nafcillin sodium monohydrate (100 mg/kg; s.c.) exhibits bactericidal activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), with MICs of 0.5 μg/mL and 64.0 μg/mL for S. aureus strains Xen-29 and Xen-1, respectively, in mice.
In Vitro

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In Vivo

Nafcillin sodium monohydrate (100 mg/kg; s.c.) exhibits bactericidal activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), with MICs of 0.5 μg/mL and 64.0 μg/mL for S. aureus strains Xen-29 and Xen-1, respectively, in mice. Animal Model:CD-1 female mice (20-25 g), with MRSA- and MSSA-infected Dosage:100 mg/kg Administration:Subcutaneous injection Result:Protected 100% of the healthy mice with MSSA infections.
Synonyms

——
Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

β-Lactamase
Research Area

Infection
Indication

——

CAS Number

7177-50-6
Formula Weight

454.47
Molecular Formula

C21H21N2O5SNa·H2O
Purity

>98% (HPLC)
Solubility

Ethanol: 20 mg/mL (44.0 mM); Water: 91 mg/mL (200.23 mM); DMSO: 91 mg/mL (200.23 mM)
SMILES

CCOC1=C(C2=CC=CC=C2C=C1)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].O.[Na+]
Chemical Name

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1.Tan AK, et al. Biochem J, 1992, 281 ( Pt 1), 191-196.

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