D3-βArr( NCGC00379308 )

Catalog No. M20139 CAS No. 662164-09-2

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

D3-βArr
Note

Research use only, not for human use.
Brief Description

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
Description

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
In Vitro

——
In Vivo

——
Synonyms

NCGC00379308
Pathway

Others
Target

Other Targets
Recptor

thyrotropin receptor (TSHR)
Research Area

——
Indication

——

Chemical Information

CAS Number

662164-09-2
Formula Weight

333.43
Molecular Formula

C20H23N5
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL (299.91 mM)
SMILES

CC(Nc1nc(nc2ccccc12)N1CCNCC1)c1ccccc1
Chemical Name

N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Neumann S et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.

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