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CREB inhibitor
CAS No. 1433286-70-4
CREB inhibitor( CREB inhibitor )
Catalog No. M20071 CAS No. 1433286-70-4
666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 148 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 345 | In Stock |
|
| 50MG | 523 | In Stock |
|
| 100MG | 731 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCREB inhibitor
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NoteResearch use only, not for human use.
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Brief Description666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
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Description666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
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In VitroCell Proliferation Assay Cell Line:CTRL or MSN-overexpressing MDA-MB-231 cells Concentration:73 nM Incubation Time:For 12hours Result:Significantly blocked the cell proliferation caused by MSN overexpression.Western Blot Analysis Cell Line:NRCMs Concentration:1 μM Incubation Time:2 hour (pretreated)Result:Effectively inhibited PE-induced CREB phosphorylation.
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In VivoAnimal Model:1-month-old female nude mice with MDA-MB-231 or T47D cells Dosage:10 mg/kg Administration:IP; once a week; for 11 weeks Result:Played a good role in inhibiting the growth of breast cancer.
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SynonymsCREB inhibitor
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorCREB
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Research Area——
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Indication——
Chemical Information
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CAS Number1433286-70-4
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Formula Weight620.52
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Molecular FormulaC33H31Cl2N3O5
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Purity>98% (HPLC)
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SolubilityDMSO: 60 mg/mL (96.7 mM)
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SMILESCl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
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Chemical Name3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xie F et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87.
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