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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - CREB inhibitor

CREB inhibitor

CAS No. 1433286-70-4

CREB inhibitor( CREB inhibitor )

Catalog No. M20071 CAS No. 1433286-70-4

666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 148 In Stock
5MG 107 In Stock
10MG 169 In Stock
25MG 345 In Stock
50MG 523 In Stock
100MG 731 In Stock
200MG 1004 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    CREB inhibitor
  • Note
    Research use only, not for human use.
  • Brief Description
    666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
  • Description
    666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
  • In Vitro
    Cell Proliferation Assay Cell Line:CTRL or MSN-overexpressing MDA-MB-231 cells Concentration:73 nM Incubation Time:For 12hours Result:Significantly blocked the cell proliferation caused by MSN overexpression.Western Blot Analysis Cell Line:NRCMs Concentration:1 μM Incubation Time:2 hour (pretreated)Result:Effectively inhibited PE-induced CREB phosphorylation.
  • In Vivo
    Animal Model:1-month-old female nude mice with MDA-MB-231 or T47D cells Dosage:10 mg/kg Administration:IP; once a week; for 11 weeks Result:Played a good role in inhibiting the growth of breast cancer.
  • Synonyms
    CREB inhibitor
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    CREB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1433286-70-4
  • Formula Weight
    620.52
  • Molecular Formula
    C33H31Cl2N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 60 mg/mL (96.7 mM)
  • SMILES
    Cl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
  • Chemical Name
    3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie F et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87.
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