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TRAM 39
CAS No. 197525-99-8
TRAM 39( 2-(2-chlorophenyl)-2,2-diphenylacetonitrile | 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile | TRAM-39 | ZINC27105797 )
Catalog No. M27729 CAS No. 197525-99-8
TRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 104 | In Stock |
|
| 25MG | 211 | In Stock |
|
| 50MG | 328 | In Stock |
|
| 100MG | 519 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1097 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTRAM 39
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NoteResearch use only, not for human use.
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Brief DescriptionTRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.
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DescriptionTRAM 39 is a selective blocker of intermediate-conductance Ca2+-activated K+channels.(In Vitro):In coeliac neurons, TRAM 39 depressed the amplitude of the prolonged conductance underlying the slow afterhyperpolarization, (gKCa2) by 57%.
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In VitroTRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells.TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells.
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In VivoTRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations.
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Synonyms2-(2-chlorophenyl)-2,2-diphenylacetonitrile | 2-Chloro-alpha,alpha-diphenylbenzeneacetonitrile | TRAM-39 | ZINC27105797
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number197525-99-8
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Formula Weight303.79
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Molecular FormulaC20H14ClN
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (164.59 mM)
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SMILESClc1ccccc1C(C#N)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chang W, et al. Pd-Catalyzed regioselective hydroesterification of 2-allylphenols to seven-membered lactones without external CO gas. Org Biomol Chem. 2016 Mar 21;14(11):3047-52.
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