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AG 99
CAS No. 122520-85-8
AG 99( (E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46 )
Catalog No. M19940 CAS No. 122520-85-8
AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 10MG | 33 | In Stock |
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| 25MG | 59 | In Stock |
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| 50MG | 82 | In Stock |
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| 100MG | 114 | In Stock |
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| 200MG | 166 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAG 99
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NoteResearch use only, not for human use.
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Brief DescriptionAG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
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DescriptionAG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
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In Vitro(E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases.
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In Vivo——
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Synonyms(E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number122520-85-8
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Formula Weight204.18
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Molecular FormulaC10H8N2O3
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL;Ethanol: 1 mg/mL;Water: Insoluble
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SMILESNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gazit A et al. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem. 1996 Dec 6;39(25):4905-11.
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