AG 99( (E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46 )

Catalog No. M19940 CAS No. 122520-85-8

AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

AG 99
Note

Research use only, not for human use.
Brief Description

AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
Description

AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
In Vitro

(E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases.
In Vivo

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Synonyms

(E)-Tyrphostin AG 99 | (E)-Tyrphostin 46 | Tyrphostin 46
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

122520-85-8
Formula Weight

204.18
Molecular Formula

C10H8N2O3
Purity

>98% (HPLC)
Solubility

DMSO: 20 mg/mL;Ethanol: 1 mg/mL;Water: Insoluble
SMILES

NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Gazit A et al. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem. 1996 Dec 6;39(25):4905-11.

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