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Lazertinib
CAS No. 1903008-80-9
Lazertinib( YH 25448 | YH25448 | GNS-1480 | GNS1480 )
Catalog No. M12983 CAS No. 1903008-80-9
Lazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 106 | In Stock |
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| 2MG | 54 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 226 | In Stock |
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| 50MG | 319 | In Stock |
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| 100MG | 458 | In Stock |
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| 200MG | 677 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLazertinib
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NoteResearch use only, not for human use.
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Brief DescriptionLazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations.
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DescriptionLazertinib (YH25448, GNS-1480) is a highly potent, mutant-selective, irreversible, brain-penetrant and orally active EGFR tyrosine-kinase inhibitors for both the T790M mutation and activating EGFR mutations; shows the beneficial for the NSCLC with brain metastasis.Lung Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsYH 25448 | YH25448 | GNS-1480 | GNS1480
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR (del19)|EGFR (T790M)|EGFR (T790M/L858R)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1903008-80-9
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Formula Weight554.66
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Molecular FormulaC30H34N8O3
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Purity>98% (HPLC)
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SolubilityEthanol: Insoluble; Water: Insoluble; DMSO: 10 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESC=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O
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Chemical NameN-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patent US20160102076 A1.
2.?Yun J, et al. Clin Cancer Res. 2019 Jan 22. pii: clincanres.2906.2018. doi: 10.1158/1078-0432.CCR-18-2906.
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