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tetrahydroxyl diphenylethylene-2-o-gluco

CAS No. 55327-45-2

tetrahydroxyl diphenylethylene-2-o-gluco( EH-201 )

Catalog No. M19812 CAS No. 55327-45-2

EH-201 is a low MW inducer of erythropoietin. EH-201 induces expression of erythropoietin PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo EH-201 treatment restores memory impairment as assessed by the passive avoidance test in SD Aβ and KA mouse models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 101 In Stock
5MG 112 In Stock
10MG 180 In Stock
25MG 303 In Stock
50MG 445 In Stock
100MG 638 In Stock
200MG 886 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    tetrahydroxyl diphenylethylene-2-o-gluco
  • Note
    Research use only, not for human use.
  • Brief Description
    EH-201 is a low MW inducer of erythropoietin. EH-201 induces expression of erythropoietin PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo EH-201 treatment restores memory impairment as assessed by the passive avoidance test in SD Aβ and KA mouse models.
  • Description
    EH-201 is a low MW inducer of erythropoietin. EH-201 induces expression of erythropoietin PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astrocytes and PC12 neuronal-like cells. In vivo EH-201 treatment restores memory impairment as assessed by the passive avoidance test in SD Aβ and KA mouse models. In the hippocampus of mice given EH-201 in their diet levels of erythropoietin PGC-1α and haemoglobin were increased. Treatment with EH-201 might be a therapeutic strategy for memory impairment in neurodegenerative disease physiological ageing or traumatic brain injury.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EH-201
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55327-45-2
  • Formula Weight
    406.38
  • Molecular Formula
    C20H22O9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    OC[C@H]1O[C@@H](Oc2c(O)cc(O)cc2\C=C\c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
  • Chemical Name
    (2S3R4S5S6R)-2-(24-dihydroxy-6-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-345-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Activating mitochondrial function and haemoglobin expression with EH‐201 an inducer of erythropoietin in neuronal cells reverses memory impairment[J]. British Journal of Pharmacology 2015 172(19):4741-4756.
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