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Aniline
CAS No. 62-53-3
Aniline( Phenylamine | Aminobenzen )
Catalog No. M19715 CAS No. 62-53-3
Aniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAniline
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NoteResearch use only, not for human use.
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Brief DescriptionAniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation.
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DescriptionAniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation. Toxicity of this agent on the spleen is characterized by hyperplasia fibrosis and vascular congestion in rats. Studies suggest that this compound causes significant increase in both p-IKKα and p-IKKβ which in-turn increases NF-κB and AP-1 binding activity. In other experiments Aniline displays a capacity to induce methemoglobinemia glutathione depletion membrane cytoskeletal changes loss of circulating blood cells and adversely affects blood stability.
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In Vitro——
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In Vivo——
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SynonymsPhenylamine | Aminobenzen
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number62-53-3
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Formula Weight93.13
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Molecular FormulaC6H7N
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESNc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bomhard E M Herbold B A . Genotoxic Activities of Aniline and its Metabolites and Their Relationship to the Carcinogenicity of Aniline in the Spleen of Rats[J]. Critical Reviews in Toxicology 2005 35(10):783-835.
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