3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group or from the replacement of any hydrogen of glycine by a heteroatom.

1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.

Pyrithioxin dihydrochloride (Pyrithioxine HCl) has anti-nociceptive and anti-allodynic effects, can promote the metabolism of glucose and amino acids in the brain, improve systemic assimilation, and can be used to study neurological diseases such as atherosclerosis.