Cart
sales@molnova.com
Cimetidine
CAS No. 51481-61-9
Cimetidine( NSC 335308 | SKF 92334 )
Catalog No. M14785 CAS No. 51481-61-9
Cimetidine is a histamine-2 (H2) receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | 50 | In Stock |
|
Biological Information
-
Product NameCimetidine
-
NoteResearch use only, not for human use.
-
Brief DescriptionCimetidine is a histamine-2 (H2) receptor antagonist.
-
DescriptionCimetidine is a histamine-2 (H2) receptor antagonist.(In Vitro):Cimetidine (SKF-92334), a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers . Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells).Cimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production.Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression.(In Vivo):Cimetidine (SKF-92334) reduceS CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice.Cimetidine exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption.
-
In VitroCimetidine (SKF-92334), a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers . Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells). Cimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production. Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression.
-
In VivoCimetidine (SKF-92334) reduceS CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice. Cimetidine exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption.
-
SynonymsNSC 335308 | SKF 92334
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorH2 receptor
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number51481-61-9
-
Formula Weight252.34
-
Molecular FormulaC10H16N6S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 51mg/ml (202.11 mM); Water: <1mg/ml; Ethanol: 3mg/ml (11.89 mM)
-
SMILESCN=C(NCCSCC1=C(C)NC=N1)NC#N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hernandez-Munoz R, et al. Lab Invest. 2000 Aug; 80(8): 1161-9.
molnova catalog
related products
-
Famotidine
Famotidine is a competitive histamine H2-receptor antagonist.
-
JNJ-5207852 dihydroc...
JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. JNJ-5207852 is a potent dibasic amine antagonist that binds potently to rat H3 receptors (Ki=1.2?nm), and has good brain penetration. In ex vivo binding studies in mice, the compound had an ED50 of 0.13?mg?kg?1, subcutaneously.
-
Tripelennamine hydro...
A first-generation antihistamine that acts primarily as H1 receptor antagonist.
