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MS049 2HCl
CAS No. ——
MS049 2HCl( —— )
Catalog No. M19404 CAS No. ——
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 52 | Get Quote |
|
| 10MG | 84 | Get Quote |
|
| 25MG | 178 | Get Quote |
|
| 50MG | 336 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
| 5MG | 52 | Get Quote |
|
| 10MG | 84 | Get Quote |
|
| 25MG | 178 | Get Quote |
|
| 50MG | 336 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMS049 2HCl
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NoteResearch use only, not for human use.
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Brief DescriptionMS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).
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DescriptionMS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130 >220 and 1.6 μM for PRMT1 PRMT3 and PRMT8 respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorPRMT4| PRMT6
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight321.28
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Molecular FormulaC15H26Cl2N2O
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Purity>98% (HPLC)
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SolubilityDMSO:30 mg/mL; Ethanol:30 mg/ml;PBS (pH7.2):10 mg/ml
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SMILESCl.Cl.CNCCN1CCC(CC1)OCc2ccccc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shen Y etal. Discovery of a Potent Selective and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6[J]. Journal of Medicinal Chemistry 2016 59(19):9124-9139.
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