Cart
sales@molnova.com
MS049 2HCl
CAS No. ——
MS049 2HCl( —— )
Catalog No. M19404 CAS No. ——
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 52 | Get Quote |
|
| 10MG | 84 | Get Quote |
|
| 25MG | 178 | Get Quote |
|
| 50MG | 336 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMS049 2HCl
-
NoteResearch use only, not for human use.
-
Brief DescriptionMS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM).
-
DescriptionMS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130 >220 and 1.6 μM for PRMT1 PRMT3 and PRMT8 respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorPRMT4| PRMT6
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight321.28
-
Molecular FormulaC15H26Cl2N2O
-
Purity>98% (HPLC)
-
SolubilityDMSO:30 mg/mL; Ethanol:30 mg/ml;PBS (pH7.2):10 mg/ml
-
SMILESCl.Cl.CNCCN1CCC(CC1)OCc2ccccc2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shen Y etal. Discovery of a Potent Selective and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6[J]. Journal of Medicinal Chemistry 2016 59(19):9124-9139.
molnova catalog
related products
-
M?89
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.?M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
-
P3FI-63
P3FI-63 is a selective KDM3B inhibitor (IC50: 7 μM) with antitumor activity for the study of fusion-positive rhabdomyosarcoma and other transcriptionally addictive cancers.
-
EZM0414
EZM0414 is a selective SEDT2 inhibitor that is mostly used to study diffuse large B lymphocytoma and recurrent or refractory multiple myeloma.
