SETDB1-TTD-IN-1

Research use only, not for human use.

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.(In Vitro):SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells. SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells. SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM).

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Chromatin/Epigenetic

Histone Demethylase

Fusion protein|RSV

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2755823-12-0

469.58

C28H31N5O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (266.20 mM)

CN1C[C@H](C[C@H](C1)NC2=NC3=C(NC=C3)C(N2CC=C)=O)C4=CC=C(C=C4)OCC5=CC=CC=C5

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(-20℃)

With Ice Pack

≥ 2 years