Glycocholic Acid Sodium Salt

Research use only, not for human use.

Glycocholic Acid Sodium Salt is a conjugated bile salt and ionic biologic detergent. It is involved in the emulsification of fats.

Glycocholate sodium is a conjugated bile salt and ionic biologic detergent. It is involved in the emulsification of fats.

Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways.

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Glycocholate sodium | Glycocholic acid sodium salt

Others

Other Targets

Others

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863-57-0

487.61

C26H42NNaO6

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (205.09 mM)

[Na+].[O-]C(=O)CNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

Sodium 2-[[(4R)-4-[(3R,7R,10S,12S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetate

(-20℃)

With Ice Pack

≥ 2 years