Calcium Levofolinate( Calcium levofolinate | CL307782 )

Catalog No. M19124 CAS No. 80433-71-2

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HPLC

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Product Name

Calcium Levofolinate
Note

Research use only, not for human use.
Brief Description

Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
Description

Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.(In Vivo):Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil.
In Vitro

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In Vivo

Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil. Animal Model:Crj:CD(SD)BR rats (5 weeks)Dosage:6, 20 or 60 mg/kg/day Administration:i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil)Result:Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
Synonyms

Calcium levofolinate | CL307782
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

——

CAS Number

80433-71-2
Formula Weight

511.5
Molecular Formula

C20H21N7O7·Ca
Purity

>98% (HPLC)
Solubility

H2O : 26.5 mg/mL 51.81 mM
SMILES

C(=O)([C@@H](NC(=O)c1ccc(cc1)NC[C@@H]1N(c2c(=O)nc([nH]c2NC1)N)C=O)CCC(=O)[O-])[O-].[Ca+2]
Chemical Name

——

1.Lebitasy M, Hecq JD, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L.J Clin Pharm Ther. 2009 Aug;34(4):423-8.

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