J-14

Research use only, not for human use.

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.

Cell Viability Assay Cell Line:A549 cells Concentration:0-100 μM Incubation Time:0 hour, 24 hours, 48 hours, 72 hours, 96 hours Result:Inhibited the growth of A549 cells in a concentration- and a time- dependent manner.Western Blot Analysis Cell Line:A549 cells Concentration:20 μM Incubation Time:48 hours, 72 hours Result:Caused not only the release of cytochrome c into the cytosol, but also the activation of caspase-3 and caspase-9.

Animal Model:Six-week-old BALB/c nude female mice injected with A549 cells Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 16 days Result:Significantly reduced the growth of human lung tumor without acute toxicity.

——

Others

Other Targets

sulfiredoxin

——

——

1043854-13-2

517.04

C28H25ClN4O2S

>98% (HPLC)

DMSO:260 mg/mL (502.86 mM; Need ultrasonic)

OC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1

——

(-20℃)

With Ice Pack

≥ 2 years