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J-14
CAS No. 1043854-13-2
J-14( —— )
Catalog No. M21559 CAS No. 1043854-13-2
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 150 | In Stock |
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| 50MG | 225 | In Stock |
|
| 100MG | 382 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJ-14
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NoteResearch use only, not for human use.
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Brief DescriptionJ-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.
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DescriptionJ-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.
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In VitroCell Viability Assay Cell Line:A549 cells Concentration:0-100 μM Incubation Time:0 hour, 24 hours, 48 hours, 72 hours, 96 hours Result:Inhibited the growth of A549 cells in a concentration- and a time- dependent manner.Western Blot Analysis Cell Line:A549 cells Concentration:20 μM Incubation Time:48 hours, 72 hours Result:Caused not only the release of cytochrome c into the cytosol, but also the activation of caspase-3 and caspase-9.
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In VivoAnimal Model:Six-week-old BALB/c nude female mice injected with A549 cells Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 16 days Result:Significantly reduced the growth of human lung tumor without acute toxicity.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorsulfiredoxin
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Research Area——
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Indication——
Chemical Information
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CAS Number1043854-13-2
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Formula Weight517.04
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Molecular FormulaC28H25ClN4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:260 mg/mL (502.86 mM; Need ultrasonic)
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SMILESOC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kim H et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74.
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