Esculentoside A( —— )

Catalog No. M18960 CAS No. 65497-07-6

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Product Name

Esculentoside A
Note

Research use only, not for human use.
Brief Description

Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways.
Description

Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmune disease through modulation on T cell-mediated adaptive immunity. Esculentoside A may play significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis.
In Vitro

——
In Vivo

Animal Model: BXSB miceDosage:20 mg/kg Administration:Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks Result: Alleviated the renal damage of LN.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

NF-κB
Research Area

Others-Field
Indication

——

CAS Number

65497-07-6
Formula Weight

826.96
Molecular Formula

C42H66O16
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (120.92 mM)
SMILES

[C@@H]1([C@H](C[C@]2([C@H]([C@@]1(CO)C)CC[C@@]1(C)[C@]3(C)CC[C@@]4(C(=O)O)CC[C@](C)(C(=O)OC)C[C@H]4C3=CC[C@H]21)C)O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](O2)CO)CO1
Chemical Name

——

1. Zhong WT,et al. Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice. J Surg Res. 2013 Nov;185(1):364-72.

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