Pipobroman

Research use only, not for human use.

Pipobroman is an anti-cancer drug that probably acts as an alkylating agent.

Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, within 3 months, to attain a response in more than 90% of patients, without clinically relevant toxicities. The 10-years risk of thrombosis of patients treated with Pipobroman is about 15%, The anti-proliferative activity of Pipobroman on bone marrow megakaryocytes seems of particular value in lowering the occurrence of post-PV and post-ET MMM, whose risk is the lowest registered with available treatments. The 10-year risk of acute leukemia with Pipobroman is 5% in PVand 3% in ET, which is only slightly higher than that expected as a natural evolution of the disease. In conclusion, the use of Pipobroman is a definite alternative to hydroxyurea in patients with PV and ET at high risk of thrombosis.

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NSC25154 | Pipobroman

Apoptosis

Apoptosis

Others

Cancer

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54-91-1

356.06

C10H16Br2N2O2

>98% (HPLC)

DMSO : ≥ 36 mg/mL; 101.11 mM

BrCCC(=O)N1CCN(CC1)C(=O)CCBr

1,1'-(piperazine-1,4-diyl)bis(3-bromopropan-1-one)

(-20℃)

With Ice Pack

≥ 2 years