Wogonoside( Wogonoside | Oroxindin )

Catalog No. M18689 CAS No. 51059-44-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Wogonoside
Note

Research use only, not for human use.
Brief Description

Wogonoside acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
Description

Wogonoside is an antifungal agent isolated from Bacopa monnieri.
In Vitro

Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:100 μM Incubation Time:9-24 h Result:Increased the expression of LC3-II and Beclin-1 expression.Inhibited the phosphorylation levels of mTOR at Ser2448 and p70S6K at Ser-389.
In Vivo

Animal Model:MDA-MB-231 orthotopic modelDosage:80 mg/kg Administration:oral gavage, once every other day Result:Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at ?orthotopic site.
Synonyms

Wogonoside | Oroxindin
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

GABA
Research Area

Cancer|Inflammation/Immunology
Indication

——

CAS Number

51059-44-0
Formula Weight

460.39
Molecular Formula

C22H20O11
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (271.51 mM)
SMILES

COc1c(cc(c2c1oc(cc2=O)c1ccccc1)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O
Chemical Name

5,7-Dihydroxy-8-methoxyflavone 7-O-beta-D-Glucuronide

1. Hui KM, et al. Biochem. Pharmacol. 2012, 64 (9): 1415–24.

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