Ac-CoA Synthase Inhibitor1

Research use only, not for human use.

ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).

MDK-6149, also known as ACSS2 Inhibitor or Ac-CoA Synthase Inhibitor I, is a Ac-CoA Synthase Inhibitor. MDK-6149 has CAS#508186-14-9. It was first reported in 2014. Cell. 159, 1591. For the convenience of scientific communication, we temporally name it as MDK-6149. The last 4 digit of its CAS# was used for name.

Ac-CoA Synthase Inhibitor1 inhibits cellular [14C]acetate uptake into both lipids and histones with an IC50 of 5 μM. Ac-CoA Synthase Inhibitor1 inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 of 6.8 μM. Ac-CoA Synthase Inhibitor1 inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC50 of 5.5 μM.

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Ac-CoA Synthase Inhibitor I | MDK6149 | ACSS2 Inhibitor

Immunology/Inflammation

IκB kinase (IKK)

ACSS2

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508186-14-9

410.51

C20H18N4O2S2

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 243.60 mM

COCCNC(=O)Nc2cc3nc(c1cccs1)c(nc3cc2)c4cccs4

1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

(-20℃)

With Ice Pack

≥ 2 years