SU-909( SU909 | SU 909 | IKKα-IN-48 )

Catalog No. M13383 CAS No. 2126749-48-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SU-909
Note

Research use only, not for human use.
Brief Description

SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM.
Description

SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.
In Vitro

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In Vivo

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Synonyms

SU909 | SU 909 | IKKα-IN-48
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB kinase (IKK)
Research Area

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Indication

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CAS Number

2126749-48-0
Formula Weight

314.323
Molecular Formula

C13H10N6O2S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide

1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066.

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