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Lycorine
CAS No. 476-28-8
Lycorine( Lycorine | Galanthidine | NSC-401360 | NSC401360 )
Catalog No. M18593 CAS No. 476-28-8
Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 46 | In Stock |
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| 50MG | 63 | In Stock |
|
| 100MG | 101 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 245 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLycorine
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NoteResearch use only, not for human use.
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Brief DescriptionLycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
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DescriptionLycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. It is a natural alkaloid extracted from the Amaryllidaceae plant family.
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In VitroCell Viability Assay Cell Line:HL-7702/SRE-Luc cells Concentration:16 hours Incubation Time:5 μM; 10 μM; 20 μM; 40 μM Result:Had no cytotoxicity on HL-7702 cells.Western Blot Analysis Cell Line:HL-7702/SRE-Luc cells Concentration:2 hours, 4 hours, 8 hours, 12 hours, 16 hours Incubation Time:10 μM; 20 μM Result:Decreased p-SREBF1, m-SREBF1, p-SREBF2 and p-SREBF1 protein expression.RT-PCR Cell Line:C8161 cells Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM Incubation Time:48 hours Result:Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.
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In VivoAnimal Model:High-fat diet (HFD)-fed C57BL/6J mice Dosage:15 mg/kg, 30 mg/kg Administration:Oral chow; once daily Result:Ameliorated high-fat diet-induced hyperlipidemia, hepatic steatosis, and insulin resistance in mice.
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SynonymsLycorine | Galanthidine | NSC-401360 | NSC401360
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PathwayEndocrinology/Hormones
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TargetATPase
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number476-28-8
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Formula Weight287.31
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Molecular FormulaC16H17NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (87.01 mM)
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SMILESC1CN2Cc3cc4c(cc3[C@H]3[C@H]2C1=C[C@@H]([C@H]3O)O)OCO4
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Chemical Name(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vrijsen R. Biol. Chem. 1986, 261 (2): 505–7.
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