BPTES( BPTES )

Catalog No. M18414 CAS No. 314045-39-1

BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	77	In Stock
2MG	42	In Stock
5MG	60	In Stock
10MG	77	In Stock
25MG	145	In Stock
50MG	213	In Stock
100MG	318	In Stock
200MG	462	In Stock
500MG	756	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BPTES
Note

Research use only, not for human use.
Brief Description

BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
Description

BPTES is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex.
In Vitro

——
In Vivo

——
Synonyms

BPTES
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Glutaminase GLS1 (KGA)
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

314045-39-1
Formula Weight

524.68
Molecular Formula

C24H24N6O2S3
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 95.30 mM;H2O : < 0.1 mg/mL
SMILES

O=C(Cc1ccccc1)Nc1nnc(s1)CCSCCc1sc(nn1)NC(=O)Cc1ccccc1
Chemical Name

N,N'-((thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Le A., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21.

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