Hematoporphyrin dihydrochloride( Hematoporphyrin IX dihydrochloride )

Catalog No. M18132 CAS No. 17696-69-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Hematoporphyrin dihydrochloride
Note

Research use only, not for human use.
Brief Description

Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
Description

Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
In Vitro

Cell Viability Assay Cell Line:U87 and U251 cells Concentration:20, 40, 60, 80, 100, 120 nM Incubation Time:60 min Result:Inhibited cell viability in a dose-dependent manner.Was more effective under the red light than white light.Apoptosis Analysis Cell Line:U87 cells Concentration:85 nM Incubation Time:60 min Result:Induced apoptotic nuclei in U87 cells with low cell density.Induced the ROS and decreased the mitochondrial membrane potential.
In Vivo

Animal Model:Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130Dosage:5, 10 mg/kg Administration:I.p. daily during the initial 10 days and biweekly for the next 2 months Result:No tumor could be palpated a few days after exposure of the rats to light.The skin healed completely and regrowth of the hair occurred.Massive coagulation necrosis of the tumor 24 h after photo treatment (×40).
Synonyms

Hematoporphyrin IX dihydrochloride
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

17696-69-4
Formula Weight

671.61
Molecular Formula

C34H40Cl2N4O6
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 50 mg/mL 74.45 mM; H2O : < 0.1 mg/mL
SMILES

Cl.C\1=c/2\[nH]/c(=C\C3=N/C(=C\c4[nH]c(c(c4C)CCC(=O)O)/C=C/4\N=C1C(=C4CCC(=O)O)C)/C(=C3C)C(C)O)/c(c2C)C(C)O.Cl
Chemical Name

——

1.Olsen, K.W.Methods Enzymol, 1986. 123: p. 324-31.

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