GTS 21 dihydrochloride( DMXB-A | DMBX-anabaseine )

Catalog No. M18083 CAS No. 156223-05-1

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Product Name

GTS 21 dihydrochloride
Note

Research use only, not for human use.
Brief Description

GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
Description

GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.(In Vitro):GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.(In Vivo):GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.
In Vitro

GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.
In Vivo

GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury. Animal Model:C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI) Dosage:4 mg/kg Administration:I.p.; 1, 3, 7, 14 and 21 days Result:Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.
Synonyms

DMXB-A | DMBX-anabaseine
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

α4β2 nAChR
Research Area

Inflammation/Immunology
Indication

——

1. Mol Med. 2014 Jun 19;20:238-47.

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