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GTS 21 dihydrochloride
CAS No. 156223-05-1
GTS 21 dihydrochloride( DMXB-A | DMBX-anabaseine )
Catalog No. M18083 CAS No. 156223-05-1
GTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | Get Quote |
|
| 10MG | 69 | Get Quote |
|
| 25MG | 105 | Get Quote |
|
| 50MG | 132 | Get Quote |
|
| 100MG | 205 | Get Quote |
|
| 200MG | 309 | Get Quote |
|
| 500MG | 516 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGTS 21 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.
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DescriptionGTS 21 dihydrochloride is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.(In Vitro):GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.(In Vivo):GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury.
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In VitroGTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively.
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In VivoGTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury. Animal Model:C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI) Dosage:4 mg/kg Administration:I.p.; 1, 3, 7, 14 and 21 days Result:Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.
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SynonymsDMXB-A | DMBX-anabaseine
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PathwayJAK/STAT Signaling
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TargetSTAT
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Recptorα4β2 nAChR
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number156223-05-1
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Formula Weight381.3
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Molecular FormulaC19H20N2O2·2HCl
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Purity>98% (HPLC)
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SolubilityDMSO : 16.5 mg/mL 43.27 mM
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SMILESCl.COc1ccc(/C=C\2/CCCN=C2c2cccnc2)c(OC)c1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mol Med. 2014 Jun 19;20:238-47.
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