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STAT3-IN-1

CAS No. 2059952-75-7

STAT3-IN-1( —— )

Catalog No. M21979 CAS No. 2059952-75-7

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 132 In Stock
2MG 77 In Stock
5MG 126 In Stock
10MG 193 In Stock
25MG 350 In Stock
50MG 512 In Stock
100MG 737 In Stock
200MG Get Quote In Stock
500MG 1516 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    STAT3-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.
  • Description
    STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis. STAT3-IN-1 induces tumor cells apoptosis in MDA-MB-231 cells.
  • In Vitro
    Apoptosis Analysis Cell Line:MDA-MB-231 cell lines.Concentration:0-10 μM.Incubation Time:48 hours.Result:The induced apoptosis rates (early and late apoptosis) at 1, 2, 5, 8 and 10 μM were 9.0%, 11.2%, 20.9%, 43.3% and 85.2% versus control 3.0%.Western Blot Analysis Cell Line:MDA-MB-231 and HT-29 cell lines.Concentration:0-10 μM.Incubation Time:48 hours.Result:Inhibited STAT3 acetylation and STAT3 tyrosine phosphorylation in MDA-MB-231 cells.Increased the expressions of these tumor-suppressor genes (PTPN6 (SHP-1), CDKN2A and DLEC1) which were related to STAT3 acetylation at Lys685.
  • In Vivo
    Animal Model:Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells.Dosage:10, 20 mg/kg. Administration:Oral administration once every other day for two weeks.Result: Arrested tumor growth with no obvious body weight loss.
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2059952-75-7
  • Formula Weight
    475.53
  • Molecular Formula
    C28H29NO6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(262.86 mM;?Need ultrasonic)
  • SMILES
    COc1cc(OC)cc(\C=C\c2ccc(NC(=O)\C=C\c3cc(OC)c(OC)c(OC)c3)cc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Li S, et al. Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. Eur J Med Chem. 2016 Nov 29;124:1006-1018.
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