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Home - Products - JAK/STAT Signaling - STAT - BP-5-087

BP-5-087

CAS No. 1803281-30-2

BP-5-087( BP 5-087 )

Catalog No. M12758 CAS No. 1803281-30-2

A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BP-5-087
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
  • Description
    A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation; restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BP 5-087
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1803281-30-2
  • Formula Weight
    770.691
  • Molecular Formula
    C36H30F8N2O6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)C1=CC=C(S(=O)(N(CC(N(C2=CC=C(C(O)=O)C(O)=C2)CC3=CC=C(C4CCCCC4)C=C3)=O)CC5=C(C)C=CC=C5)=O)C=C1
  • Chemical Name
    4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597. 2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.
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