Chetomin

Research use only, not for human use.

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.

Western Blot Analysis Cell Line:H460 and H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Showed progressively lower expression of several survival-promoting proteins promoted by Hsp90/HIF1α activity, including insulin-like growth factor 1 (IGF1 R), epidermal growth factor receptor (EGFR), Src, mitogen-activated protein kinase kinase 1/2 (MEK1/2), activation of protein kinase B (Akt), and mammalian target of rapamycin (mTOR).Cell Cycle Analysis Cell Line:H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Elicited cell cycle arrest in susceptible and chemoresistant NSCLC cell lines.

Animal Model:Mouse Dosage:0~100 mg/kg Administration:P.o.Result:Inhibited lung tumorigenesis in NSCLC mouse models.

Chetomin | CTM | NSC-289491 | NSC 289491

Others

Other Targets

HIF-1

Cancer

——

1403-36-7

710.87

C31H30N6O6S4

>98% (HPLC)

——

CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C

2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

(-20℃)

With Ice Pack

≥ 2 years