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Chromenone 1
CAS No. 1639929-29-5
Chromenone 1( —— )
Catalog No. M35539 CAS No. 1639929-29-5
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 109 | In Stock |
|
| 5MG | 107 | In Stock |
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| 10MG | 157 | In Stock |
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| 25MG | 236 | In Stock |
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| 50MG | 324 | In Stock |
|
| 100MG | 442 | In Stock |
|
| 200MG | 594 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChromenone 1
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NoteResearch use only, not for human use.
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Brief DescriptionChromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
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DescriptionChromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
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In VitroChromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTGF-beta/Smad
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Research Area——
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Indication——
Chemical Information
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CAS Number1639929-29-5
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Formula Weight357.29
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Molecular FormulaC18H10F3N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (279.88 mM; Ultrasonic )
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SMILESO=C1C(=C(OC=2C1=CC=CC2)N3C=NC=N3)C4=CC=C(C(F)(F)F)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990. ?
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