UNC669

Research use only, not for human use.

UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.

UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.

L3MBTL1, a paralogue of Drosophila tumor suppressor lethal(3)malignant brain tumor (l(3)mbt), binds histones in a methylation state-dependent manner and contributes to higher order chromatin structure and transcriptional repression. Similar to L3MBTL1, the closely related protein, L3MBTL3, also contains three MBT repeats and has been shown to play a role in meduloblastoma formation and normal hematopoiesis in humans.

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Autophagy

Autophagy

L3MBTL1| L3MBTL3| L3MBTL4

Others-Field

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1314241-44-5

338.24

C15H20BrN3O

>98% (HPLC)

DMSO : 50 mg/mL 147.82 mM;

c1c(cncc1Br)C(=O)N1CCC(CC1)N1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years