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Dolasetron
CAS No. 115956-12-2
Dolasetron( HSDB 7565 | HSDB7565 | Dolasetron | Dolasetronum )
Catalog No. M17847 CAS No. 115956-12-2
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 57 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 276 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 682 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDolasetron
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NoteResearch use only, not for human use.
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Brief DescriptionDolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
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DescriptionDolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
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In Vitro——
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In Vivo——
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SynonymsHSDB 7565 | HSDB7565 | Dolasetron | Dolasetronum
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PathwayOthers
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TargetOther Targets
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Recptor5-HT3
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number115956-12-2
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Formula Weight324.38
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Molecular FormulaC19H20N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 300 mg/mL; 924.87 mM
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SMILES[H][C@]12C[C@@H](C[C@@H]3C[C@H](C1)C(=O)CN23)OC(=O)c1c[nH]c2ccccc12
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Chemical Name(6R)-3-oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Faria C,etal.Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis.Am Health Drug Benefits. 2014 Jan;7(1):50-8.
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