Rg3039( RG3039 | RG 3039 | PF 06687859 | PF-06687859 )

Catalog No. M17746 CAS No. 1005504-62-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Rg3039
Note

Research use only, not for human use.
Brief Description

RG3039 (PF-06687859) is a potent DcpS inhibitor.
Description

RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
In Vitro

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In Vivo

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Synonyms

RG3039 | RG 3039 | PF 06687859 | PF-06687859
Pathway

Cell Cycle/DNA Damage
Target

GPR
Recptor

DcpS
Research Area

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Indication

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CAS Number

1005504-62-0
Formula Weight

432.35
Molecular Formula

C21H23Cl2N5O
Purity

>98% (HPLC)
Solubility

DMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL
SMILES

C1CN(CCC1COc1cccc2c1c(nc(n2)N)N)Cc1c(cccc1Cl)Cl
Chemical Name

5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine

1. Rocky G. Gogliotti, et al. Hum Mol Genet. 2013 Oct 15; 22(20): 4084–4101.

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