Cart
sales@molnova.com
Rg3039
CAS No. 1005504-62-0
Rg3039( RG3039 | RG 3039 | PF 06687859 | PF-06687859 )
Catalog No. M17746 CAS No. 1005504-62-0
RG3039 (PF-06687859) is a potent DcpS inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 76 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 245 | In Stock |
|
| 100MG | 394 | In Stock |
|
| 500MG | 887 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRg3039
-
NoteResearch use only, not for human use.
-
Brief DescriptionRG3039 (PF-06687859) is a potent DcpS inhibitor.
-
DescriptionRG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
-
In Vitro——
-
In Vivo——
-
SynonymsRG3039 | RG 3039 | PF 06687859 | PF-06687859
-
PathwayCell Cycle/DNA Damage
-
TargetGPR
-
RecptorDcpS
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1005504-62-0
-
Formula Weight432.35
-
Molecular FormulaC21H23Cl2N5O
-
Purity>98% (HPLC)
-
SolubilityDMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL
-
SMILESC1CN(CCC1COc1cccc2c1c(nc(n2)N)N)Cc1c(cccc1Cl)Cl
-
Chemical Name5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rocky G. Gogliotti, et al. Hum Mol Genet. 2013 Oct 15; 22(20): 4084–4101.
molnova catalog
related products
-
GTPL5846
6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
-
3-Hydroxyoctanoic Ac...
3-Hydroxyoctanoic Acid is one of the hydroxy-carboxylic acids (HCAs) that serve as intermediates of energy metabolism. It is an agonist of the orphan receptor GPR109B.
-
NOX-6-18
NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.
